Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection.

• मुख्य लेखकों: Sridhar Arumugam (लेखक), Junfei Wei (लेखक), Zhuyun Liu (लेखक), David Abraham (लेखक), Aaron Bell (लेखक), Maria Elena Bottazzi (लेखक), Peter J Hotez (लेखक), Bin Zhan (लेखक), Sara Lustigman (लेखक), Thomas R Klei (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2016-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

BACKGROUND:The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for the development of an O. volvulus vaccine. The B. malayi gerbil model was used to confirm the efficacy of these Ov vaccine candidat...