Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

• Main Authors: Siyuan Tang (Author), Miguel Garzon Sanz (Author), Oliver Smith (Author), Andreas Krämer (Author), Daniel Egbase (Author), Paul W. Caton (Author), Stefan Knapp (Author), Sam Butterworth (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The cofactor nicotinamide adenine dinucleotide (NAD+) plays a key role in a wide range of physiological processes and maintaining or enhancing NAD+ levels is an established approach to enhancing healthy aging. Recently, several classes of nicotinamide phosphoribosyl transferase (NAMPT) activators ha...