Chemistry-led investigations into the mode of action of NAMPT activators, resulting in the discovery of non-pyridyl class NAMPT activators

• Auteurs principaux: Siyuan Tang (Auteur), Miguel Garzon Sanz (Auteur), Oliver Smith (Auteur), Andreas Krämer (Auteur), Daniel Egbase (Auteur), Paul W. Caton (Auteur), Stefan Knapp (Auteur), Sam Butterworth (Auteur)
• Format: Livre
• Publié: Elsevier, 2023-02-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The cofactor nicotinamide adenine dinucleotide (NAD+) plays a key role in a wide range of physiological processes and maintaining or enhancing NAD+ levels is an established approach to enhancing healthy aging. Recently, several classes of nicotinamide phosphoribosyl transferase (NAMPT) activators ha...