A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors

• Main Authors: Yueshan Sun (Author), Hong Li (Author), Lei Liu (Author), Xiaoqin Bai (Author), Liping Wu (Author), Jing Shan (Author), Xiaobin Sun (Author), Qiong Wang (Author), Yuanbiao Guo (Author)
• Format: Book
• Published: MDPI AG, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mast cell (MC) plays a central role in intestinal permeability; however, few MC-targeting drugs are currently available for protection of the intestinal barrier in clinical practice. A nonfluorinated Lidocaine analog 2-diethylamino-N-2,5-dimethylphenyl acetamide (JM25-1) displays anti-allergic effec...