A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors

• প্রধান লেখক: Yueshan Sun (লেখক), Hong Li (লেখক), Lei Liu (লেখক), Xiaoqin Bai (লেখক), Liping Wu (লেখক), Jing Shan (লেখক), Xiaobin Sun (লেখক), Qiong Wang (লেখক), Yuanbiao Guo (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2022-12-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Mast cell (MC) plays a central role in intestinal permeability; however, few MC-targeting drugs are currently available for protection of the intestinal barrier in clinical practice. A nonfluorinated Lidocaine analog 2-diethylamino-N-2,5-dimethylphenyl acetamide (JM25-1) displays anti-allergic effec...