A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors

• Главные авторы: Yueshan Sun (Автор), Hong Li (Автор), Lei Liu (Автор), Xiaoqin Bai (Автор), Liping Wu (Автор), Jing Shan (Автор), Xiaobin Sun (Автор), Qiong Wang (Автор), Yuanbiao Guo (Автор)
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• Опубликовано: MDPI AG, 2022-12-01T00:00:00Z.
• Предметы: article
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Mast cell (MC) plays a central role in intestinal permeability; however, few MC-targeting drugs are currently available for protection of the intestinal barrier in clinical practice. A nonfluorinated Lidocaine analog 2-diethylamino-N-2,5-dimethylphenyl acetamide (JM25-1) displays anti-allergic effec...