CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis

• Main Authors: Kenneth CP Cheung (Author), Jiao Ma (Author), Lu Wang (Author), Xingxuan Chen (Author), Silvia Fanti (Author), Mingzhang Li (Author), Loiola Rodrigo Azevedo (Author), Fabien Gosselet (Author), Hao Shen (Author), Xiaojiao Zheng (Author), Aiping Lu (Author), Wei Jia (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synovitis is characterized by a distinctmetabolic profile featuring the accumulation of lactate, a byproduct of cellular metabolism within inflamed joints. This study reveals that the activation of the CD31 signal by lactate instigates a metabolic shift, specifically initiating endothelial cell auto...