CD31 orchestrates metabolic regulation in autophagy pathways of rheumatoid arthritis

• मुख्य लेखकों: Kenneth CP Cheung (लेखक), Jiao Ma (लेखक), Lu Wang (लेखक), Xingxuan Chen (लेखक), Silvia Fanti (लेखक), Mingzhang Li (लेखक), Loiola Rodrigo Azevedo (लेखक), Fabien Gosselet (लेखक), Hao Shen (लेखक), Xiaojiao Zheng (लेखक), Aiping Lu (लेखक), Wei Jia (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2024-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Synovitis is characterized by a distinctmetabolic profile featuring the accumulation of lactate, a byproduct of cellular metabolism within inflamed joints. This study reveals that the activation of the CD31 signal by lactate instigates a metabolic shift, specifically initiating endothelial cell auto...