Reactive oxygen species induced structural alterations of substance P

• Autori principali: Y. T. Konttinen (Autore), P. Kemppinen (Autore), M. Segerberg (Autore), T. Sorsa (Autore), H. Saari (Autore), M. Hukkanen (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 1992-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Substance P (SP1-11) was exposed to a continuous flux of superoxide (O2-) or hydroxyl radicals (.OH) in a hypoxanthine (HX)/xanthine oxidase (86 mU) system in the presence of 1 mM deferoxamine and 40 mM D-mannitol or 50 μM FeCI3. 6H2O and 50 μM EDTA, respectively. O2- caused fragmentation between th...