Reactive oxygen species induced structural alterations of substance P

• Main Authors: Y. T. Konttinen (Author), P. Kemppinen (Author), M. Segerberg (Author), T. Sorsa (Author), H. Saari (Author), M. Hukkanen (Author)
• Format: Book
• Published: Hindawi Limited, 1992-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Substance P (SP1-11) was exposed to a continuous flux of superoxide (O2-) or hydroxyl radicals (.OH) in a hypoxanthine (HX)/xanthine oxidase (86 mU) system in the presence of 1 mM deferoxamine and 40 mM D-mannitol or 50 μM FeCI3. 6H2O and 50 μM EDTA, respectively. O2- caused fragmentation between th...