Structure of human GPR119-Gs complex binding APD597 and characterization of GPR119 binding agonists
The rhodopsin-like receptor GPR119 plays a crucial role in glucose homeostasis and is an emerging target for the treatment of type 2 diabetes mellitus. In this study, we analyzed the structure of GPR119 with the agonist APD597 bound and in complex with the downstream G protein trimer by single parti...
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| Main Authors: | , , , , , , |
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| Format: | Book |
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Frontiers Media S.A.,
2024-01-01T00:00:00Z.
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