Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site
Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). Current antiandrogen therapies induce resistant mutations at the hormone binding pocket (HBP) that convert the activity of these agents from antagonist to agonist. Thus, there is a high unmet me...
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Frontiers Media S.A.,
2018-11-01T00:00:00Z.
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