Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site

• প্রধান লেখক: Yangguang Liu (লেখক), Meng Wu (লেখক), Tianqi Wang (লেখক), Yongli Xie (লেখক), Xiangling Cui (লেখক), Liujun He (লেখক), Yang He (লেখক), Xiaoyu Li (লেখক), Mingliang Liu (লেখক), Laixing Hu (লেখক), Shan Cen (লেখক), Jinming Zhou (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). Current antiandrogen therapies induce resistant mutations at the hormone binding pocket (HBP) that convert the activity of these agents from antagonist to agonist. Thus, there is a high unmet me...