Structural Based Screening of Antiandrogen Targeting Activation Function-2 Binding Site

• Main Authors: Yangguang Liu (Author), Meng Wu (Author), Tianqi Wang (Author), Yongli Xie (Author), Xiangling Cui (Author), Liujun He (Author), Yang He (Author), Xiaoyu Li (Author), Mingliang Liu (Author), Laixing Hu (Author), Shan Cen (Author), Jinming Zhou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Androgen receptor (AR) plays a critical role in the development and progression of prostate cancer (PCa). Current antiandrogen therapies induce resistant mutations at the hormone binding pocket (HBP) that convert the activity of these agents from antagonist to agonist. Thus, there is a high unmet me...