Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes

• Main Authors: Richard Sherva (Author), Congcong Zhu (Author), Leah Wetherill (Author), Howard J. Edenberg (Author), Emma Johnson (Author), Louisa Degenhardt (Author), Arpana Agrawal (Author), Nicholas G. Martin (Author), Elliot Nelson (Author), Henry R. Kranzler (Author), Joel Gelernter (Author), Lindsay A. Farrer (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids, and to a lesser extent cocaine, contribute to a large percentage of this health burden. Despite their high heritability, few genetic risk loci have been identified for either opioid or cocaine depend...