Ensuring Sufficient Trough Plasma Concentrations for Broad-Spectrum Beta-Lactam Antibiotics in Children With Malignancies: Beware of Augmented Renal Clearance!

• Main Authors: Pascal André (Author), Léonore Diezi (Author), Kim Dao (Author), Pierre Alex Crisinel (Author), Laura E. Rothuizen (Author), Haithem Chtioui (Author), Laurent Arthur Decosterd (Author), Manuel Diezi (Author), Sandra Asner (Author), Thierry Buclin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Broad-spectrum beta-lactams are commonly prescribed for empirical or selective treatment of bacterial infections in children with malignancies. In the immunocompromised, appropriate concentration exposure is crucial to ensure antimicrobial efficacy. Augmented renal clearance (ARC) is i...