A Novel Statin Compound from Monacolin J Produced Using CYP102A1-Catalyzed Regioselective C-Hydroxylation

• Main Authors: Ngoc Tan Cao (Author), Ngoc Anh Nguyen (Author), Chan Mi Park (Author), Gun Su Cha (Author), Ki Deok Park (Author), Chul-Ho Yun (Author)
• Format: Bog
• Udgivet: MDPI AG, 2021-09-01T00:00:00Z.
• Fag: article
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Statins inhibit the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), which is the rate-limiting enzyme in cholesterol biosynthesis. Statin therapy reduces morbidity and mortality in those who are at high risk of cardiovascular disease. Monacolin J is a statin compound, which is...