A Novel Statin Compound from Monacolin J Produced Using CYP102A1-Catalyzed Regioselective C-Hydroxylation

• Váldodahkkit: Ngoc Tan Cao (Dahkki), Ngoc Anh Nguyen (Dahkki), Chan Mi Park (Dahkki), Gun Su Cha (Dahkki), Ki Deok Park (Dahkki), Chul-Ho Yun (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2021-09-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Statins inhibit the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase), which is the rate-limiting enzyme in cholesterol biosynthesis. Statin therapy reduces morbidity and mortality in those who are at high risk of cardiovascular disease. Monacolin J is a statin compound, which is...