Discovery of LAH-1 as potent c-Met inhibitor for the treatment of non-small cell lung cancer

• Main Authors: Lijie Sima (Author), Zhongyuan Wang (Author), Ling Yu (Author), Youli Hou (Author), Dongsheng Zhao (Author), Bilan Luo (Author), Weike Liao (Author), Xinfu Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRCTDysregulated HGF/c-Met pathway has been implicated in multiple human cancers and has become an attractive target for cancer intervention. Herein, we report the discovery of N-(3-fluoro-4-((2-(3-hydroxyazetidine-1-carboxamido)pyridin-4-yl)oxy)phenyl)-1-(4-fluorophenyl)-4-methyl-6-oxo-1,6-dihyd...