3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine <i>N</i>-acetyltransferase, in Mycobacteria

• Main Authors: Neha Agre (Author), Nilesh Tawari (Author), Arundhati Maitra (Author), Antima Gupta (Author), Tulika Munshi (Author), Mariam Degani (Author), Sanjib Bhakta (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, the inhibitory potential of 3-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives was evaluated against a panel of bacteria, as well as mammalian cell lines to determine their therapeutic index. In addition, we investigated the mechanism of antibiotic action of the derivatives to identify...