3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine <i>N</i>-acetyltransferase, in Mycobacteria

• Hoofdauteurs: Neha Agre (Auteur), Nilesh Tawari (Auteur), Arundhati Maitra (Auteur), Antima Gupta (Auteur), Tulika Munshi (Auteur), Mariam Degani (Auteur), Sanjib Bhakta (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

In this study, the inhibitory potential of 3-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives was evaluated against a panel of bacteria, as well as mammalian cell lines to determine their therapeutic index. In addition, we investigated the mechanism of antibiotic action of the derivatives to identify...