3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine <i>N</i>-acetyltransferase, in Mycobacteria

• Päätekijät: Neha Agre (Tekijä), Nilesh Tawari (Tekijä), Arundhati Maitra (Tekijä), Antima Gupta (Tekijä), Tulika Munshi (Tekijä), Mariam Degani (Tekijä), Sanjib Bhakta (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2020-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

In this study, the inhibitory potential of 3-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives was evaluated against a panel of bacteria, as well as mammalian cell lines to determine their therapeutic index. In addition, we investigated the mechanism of antibiotic action of the derivatives to identify...