A Retinoid X Receptor Agonist Directed to the Large Intestine Ameliorates T-Cell-Mediated Colitis in Mice

• Main Authors: Ryohtaroh Matsumoto (Author), Daisuke Takahashi (Author), Masaki Watanabe (Author), Shunsuke Nakatani (Author), Yuta Takamura (Author), Yuji Kurosaki (Author), Hiroki Kakuta (Author), Koji Hase (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retinoid X receptor (RXR) is a nuclear receptor that heterodimerizes with several nuclear receptors, integrating ligand-mediated signals across the heterodimers. Synthetic RXR agonists have been developed to cure certain inflammatory diseases, including inflammatory bowel diseases (IBDs). However, p...