Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites

• Main Authors: Mari L. Lund (Author), Kristoffer L. Egerod (Author), Maja S. Engelstoft (Author), Oksana Dmytriyeva (Author), Elvar Theodorsson (Author), Bhavik A. Patel (Author), Thue W. Schwartz (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: 5-HT storing enterochromaffin (EC) cells are believed to respond to nutrient and gut microbial components, and 5-HT receptor-expressing afferent vagal neurons have been described to be the major sensors of nutrients in the GI-tract. However, the molecular mechanism through which EC cells...