LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and G_iα dependent PI-3kinase signalling

• Main Authors: Ngkelo Anta (Author), Meja Koremu (Author), Yeadon Mike (Author), Adcock Ian (Author), Kirkham Paul A (Author)
• Format: Book
• Published: BMC, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>COPD is a disease of innate immunity and bacterial infections are a dominant cause of exacerbations in the later stages resulting in poor health and high mortality. The pathogen-associated molecular pattern (PAMP) lipopolysaccharide (LPS) is sensed by immune cell...