Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation

• Главные авторы: Usama A. Fahmy (Автор), Shaimaa M. Badr-Eldin (Автор), Osama A. A. Ahmed (Автор), Hibah M. Aldawsari (Автор), Singkome Tima (Автор), Hani Z. Asfour (Автор), Mohammed W. Al-Rabia (Автор), Aya A. Negm (Автор), Muhammad H. Sultan (Автор), Osama A. A. Madkhali (Автор), Nabil A. Alhakamy (Автор)
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• Опубликовано: MDPI AG, 2020-05-01T00:00:00Z.
• Предметы: article
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Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavailability of 33% owing to its exposure to the hepatic first-p...