Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation

• Main Authors: Usama A. Fahmy (Author), Shaimaa M. Badr-Eldin (Author), Osama A. A. Ahmed (Author), Hibah M. Aldawsari (Author), Singkome Tima (Author), Hani Z. Asfour (Author), Mohammed W. Al-Rabia (Author), Aya A. Negm (Author), Muhammad H. Sultan (Author), Osama A. A. Madkhali (Author), Nabil A. Alhakamy (Author)
• Format: Book
• Published: MDPI AG, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavailability of 33% owing to its exposure to the hepatic first-p...