Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation

• Váldodahkkit: Usama A. Fahmy (Dahkki), Shaimaa M. Badr-Eldin (Dahkki), Osama A. A. Ahmed (Dahkki), Hibah M. Aldawsari (Dahkki), Singkome Tima (Dahkki), Hani Z. Asfour (Dahkki), Mohammed W. Al-Rabia (Dahkki), Aya A. Negm (Dahkki), Muhammad H. Sultan (Dahkki), Osama A. A. Madkhali (Dahkki), Nabil A. Alhakamy (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2020-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavailability of 33% owing to its exposure to the hepatic first-p...