Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo/In Vivo Evaluation

• Autores principales: Usama A. Fahmy (Autor), Shaimaa M. Badr-Eldin (Autor), Osama A. A. Ahmed (Autor), Hibah M. Aldawsari (Autor), Singkome Tima (Autor), Hani Z. Asfour (Autor), Mohammed W. Al-Rabia (Autor), Aya A. Negm (Autor), Muhammad H. Sultan (Autor), Osama A. A. Madkhali (Autor), Nabil A. Alhakamy (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2020-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder. FLB is a centrally acting drug that has a low oral bioavailability of 33% owing to its exposure to the hepatic first-p...