Structural Complementarity of Bruton's Tyrosine Kinase and Its Inhibitors for Implication in B-Cell Malignancies and Autoimmune Diseases

• Main Authors: Asim Najmi (Author), Neelaveni Thangavel (Author), Anugeetha Thacheril Mohanan (Author), Marwa Qadri (Author), Mohammed Albratty (Author), Safeena Eranhiyil Ashraf (Author), Safaa Fathy Saleh (Author), Maryam Nayeem (Author), Syam Mohan (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bruton's tyrosine kinase (BTK) is a critical component in B-cell receptor (BCR) signaling and is also expressed in haematogenic and innate immune cells. Inhibition of BTK hyperactivity is implicated in B-cell malignancies and autoimmune diseases. This review derives the structural complementari...