Structural Complementarity of Bruton's Tyrosine Kinase and Its Inhibitors for Implication in B-Cell Malignancies and Autoimmune Diseases

• Päätekijät: Asim Najmi (Tekijä), Neelaveni Thangavel (Tekijä), Anugeetha Thacheril Mohanan (Tekijä), Marwa Qadri (Tekijä), Mohammed Albratty (Tekijä), Safeena Eranhiyil Ashraf (Tekijä), Safaa Fathy Saleh (Tekijä), Maryam Nayeem (Tekijä), Syam Mohan (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2023-03-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Bruton's tyrosine kinase (BTK) is a critical component in B-cell receptor (BCR) signaling and is also expressed in haematogenic and innate immune cells. Inhibition of BTK hyperactivity is implicated in B-cell malignancies and autoimmune diseases. This review derives the structural complementari...