Structural Complementarity of Bruton's Tyrosine Kinase and Its Inhibitors for Implication in B-Cell Malignancies and Autoimmune Diseases

• 主要な著者: Asim Najmi (著者), Neelaveni Thangavel (著者), Anugeetha Thacheril Mohanan (著者), Marwa Qadri (著者), Mohammed Albratty (著者), Safeena Eranhiyil Ashraf (著者), Safaa Fathy Saleh (著者), Maryam Nayeem (著者), Syam Mohan (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2023-03-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Bruton's tyrosine kinase (BTK) is a critical component in B-cell receptor (BCR) signaling and is also expressed in haematogenic and innate immune cells. Inhibition of BTK hyperactivity is implicated in B-cell malignancies and autoimmune diseases. This review derives the structural complementari...