A Critical Review of Chloroquine and Hydroxychloroquine as Potential Adjuvant Agents for Treating People with Cancer

• Главные авторы: Amal Kamal Abdel-Aziz (Автор), Mona Kamal Saadeldin (Автор), Ahmed Hamed Salem (Автор), Safaa A. Ibrahim (Автор), Samia Shouman (Автор), Ashraf B. Abdel-Naim (Автор), Roberto Orecchia (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2022-10-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Chloroquine (CQ) and hydroxychloroquine (HCQ) have been used to treat malaria and autoimmune diseases for more than 70 years; they also have immunomodulatory and anticancer effects, which are linked to autophagy and autophagy-independent mechanisms. Herein, we review the pharmacokinetics, preclinica...