A target‐mediated drug disposition population pharmacokinetic model of GC1118, a novel anti‐EGFR antibody, in patients with solid tumors

• Автори: Tae Kyu Chung (Автор), Hyun A. Lee (Автор), Sang‐In Park (Автор), Do‐Youn Oh (Автор), Keun‐Wook Lee (Автор), Jin Won Kim (Автор), Jee Hyun Kim (Автор), Ahmi Woo (Автор), Su Jin Lee (Автор), Yung‐Jue Bang (Автор), Howard Lee (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2021-05-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract GC1118 is a monoclonal antibody for epidermal growth factor receptor (EGFR) that is currently under clinical development to treat patients with solid tumors. In this study, the pharmacokinetics (PKs) of GC1118 were modeled in solid tumor patients who received a 2‐h intravenous infusion of G...