A target‐mediated drug disposition population pharmacokinetic model of GC1118, a novel anti‐EGFR antibody, in patients with solid tumors

• Main Authors: Tae Kyu Chung (Author), Hyun A. Lee (Author), Sang‐In Park (Author), Do‐Youn Oh (Author), Keun‐Wook Lee (Author), Jin Won Kim (Author), Jee Hyun Kim (Author), Ahmi Woo (Author), Su Jin Lee (Author), Yung‐Jue Bang (Author), Howard Lee (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract GC1118 is a monoclonal antibody for epidermal growth factor receptor (EGFR) that is currently under clinical development to treat patients with solid tumors. In this study, the pharmacokinetics (PKs) of GC1118 were modeled in solid tumor patients who received a 2‐h intravenous infusion of G...