A multi-task FP-GNN framework enables accurate prediction of selective PARP inhibitors

• Главные авторы: Daiqiao Ai (Автор), Jingxing Wu (Автор), Hanxuan Cai (Автор), Duancheng Zhao (Автор), Yihao Chen (Автор), Jiajia Wei (Автор), Jianrong Xu (Автор), Jiquan Zhang (Автор), Ling Wang (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

PARP (poly ADP-ribose polymerase) family is a crucial DNA repair enzyme that responds to DNA damage, regulates apoptosis, and maintains genome stability; therefore, PARP inhibitors represent a promising therapeutic strategy for the treatment of various human diseases including COVID-19. In this stud...