A multi-task FP-GNN framework enables accurate prediction of selective PARP inhibitors

• Main Authors: Daiqiao Ai (Author), Jingxing Wu (Author), Hanxuan Cai (Author), Duancheng Zhao (Author), Yihao Chen (Author), Jiajia Wei (Author), Jianrong Xu (Author), Jiquan Zhang (Author), Ling Wang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PARP (poly ADP-ribose polymerase) family is a crucial DNA repair enzyme that responds to DNA damage, regulates apoptosis, and maintains genome stability; therefore, PARP inhibitors represent a promising therapeutic strategy for the treatment of various human diseases including COVID-19. In this stud...