Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes

• Main Authors: Mohamad-Reza Aghanoori (Author), Darrell R. Smith (Author), Shiva Shariati-Ievari (Author), Andrew Ajisebutu (Author), Annee Nguyen (Author), Fiona Desmond (Author), Carlos H.A. Jesus (Author), Xiajun Zhou (Author), Nigel A. Calcutt (Author), Michel Aliani (Author), Paul Fernyhough (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) of ani...