Insulin-like growth factor-1 activates AMPK to augment mitochondrial function and correct neuronal metabolism in sensory neurons in type 1 diabetes

• Päätekijät: Mohamad-Reza Aghanoori (Tekijä), Darrell R. Smith (Tekijä), Shiva Shariati-Ievari (Tekijä), Andrew Ajisebutu (Tekijä), Annee Nguyen (Tekijä), Fiona Desmond (Tekijä), Carlos H.A. Jesus (Tekijä), Xiajun Zhou (Tekijä), Nigel A. Calcutt (Tekijä), Michel Aliani (Tekijä), Paul Fernyhough (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2019-02-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Objective: Diabetic sensorimotor polyneuropathy (DSPN) affects approximately half of diabetic patients leading to significant morbidity. There is impaired neurotrophic growth factor signaling, AMP-activated protein kinase (AMPK) activity and mitochondrial function in dorsal root ganglia (DRG) of ani...