Novel Small Molecule Glucagon-Like Peptide-1 Receptor Agonist S6 Stimulates Insulin Secretion From Rat Islets

• Main Authors: Xiaohua Yang (Author), Min Zhang (Author), Zhihong Lu (Author), Linping Zhi (Author), Huan Xue (Author), Tao Liu (Author), Mengmeng Liu (Author), Lijuan Cui (Author), Zhihong Liu (Author), Peifeng He (Author), Yunfeng Liu (Author), Yi Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glucagon-like peptide-1 receptor (GLP-1R) agonist-based therapeutics for type 2 diabetes mellitus have attracted worldwide attention. However, there are challenges in the development of small molecule GLP-1R agonists owing to the complexity of ligand recognition and signal induction mechanisms. Here...