Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens.

• Main Authors: Gregory J Crowther (Author), Michael L Booker (Author), Min He (Author), Ting Li (Author), Sylvine Raverdy (Author), Jacopo F Novelli (Author), Panqing He (Author), Natalie R G Dale (Author), Amy M Fife (Author), Robert H Barker (Author), Martin L Kramer (Author), Wesley C Van Voorhis (Author), Clotilde K S Carlow (Author), Ming-Wei Wang (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia malayi, a cause of lymphatic filariasis (LF). iPGAM's active site is small and hydrophilic, i...