Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens.

• Autores principales: Gregory J Crowther (Autor), Michael L Booker (Autor), Min He (Autor), Ting Li (Autor), Sylvine Raverdy (Autor), Jacopo F Novelli (Autor), Panqing He (Autor), Natalie R G Dale (Autor), Amy M Fife (Autor), Robert H Barker (Autor), Martin L Kramer (Autor), Wesley C Van Voorhis (Autor), Clotilde K S Carlow (Autor), Ming-Wei Wang (Autor)
• Formato: Libro
• Publicado: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia malayi, a cause of lymphatic filariasis (LF). iPGAM's active site is small and hydrophilic, i...