Cofactor-independent phosphoglycerate mutase from nematodes has limited druggability, as revealed by two high-throughput screens.

• Asıl Yazarlar: Gregory J Crowther (Yazar), Michael L Booker (Yazar), Min He (Yazar), Ting Li (Yazar), Sylvine Raverdy (Yazar), Jacopo F Novelli (Yazar), Panqing He (Yazar), Natalie R G Dale (Yazar), Amy M Fife (Yazar), Robert H Barker (Yazar), Martin L Kramer (Yazar), Wesley C Van Voorhis (Yazar), Clotilde K S Carlow (Yazar), Ming-Wei Wang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2014-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Cofactor-independent phosphoglycerate mutase (iPGAM) is essential for the growth of C. elegans but is absent from humans, suggesting its potential as a drug target in parasitic nematodes such as Brugia malayi, a cause of lymphatic filariasis (LF). iPGAM's active site is small and hydrophilic, i...