Targeted Metabolomics Analysis Suggests That Tacrolimus Alters Protection against Oxidative Stress

• Main Authors: Marie Joncquel (Author), Julie Labasque (Author), Julie Demaret (Author), Marie-Adélaïde Bout (Author), Aghilès Hamroun (Author), Benjamin Hennart (Author), Mathieu Tronchon (Author), Magali Defevre (Author), Isabelle Kim (Author), Alain Kerckhove (Author), Laurence George (Author), Mylène Gilleron (Author), Anne-Frédérique Dessein (Author), Farid Zerimech (Author), Guillaume Grzych (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tacrolimus (FK506) is an immunosuppressant that is experiencing a continuous rise in usage worldwide. The related side effects are known to be globally dose-dependent. Despite numerous studies on FK506, the mechanisms underlying FK506 toxicity are still not well understood. It is therefore essential...