Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells

• Main Authors: Isabel Pagani (Author), Linda Ottoboni (Author), Paola Panina-Bordignon (Author), Gianvito Martino (Author), Guido Poli (Author), Sarah Taylor (Author), Jeremy E. Turnbull (Author), Edwin Yates (Author), Elisa Vicenzi (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from death following ZIKV infection. Although heparin...