Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells

• Hoofdauteurs: Isabel Pagani (Auteur), Linda Ottoboni (Auteur), Paola Panina-Bordignon (Auteur), Gianvito Martino (Auteur), Guido Poli (Auteur), Sarah Taylor (Auteur), Jeremy E. Turnbull (Auteur), Edwin Yates (Auteur), Elisa Vicenzi (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from death following ZIKV infection. Although heparin...