Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects That Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells

• Autores principales: Isabel Pagani (Autor), Linda Ottoboni (Autor), Paola Panina-Bordignon (Autor), Gianvito Martino (Autor), Guido Poli (Autor), Sarah Taylor (Autor), Jeremy E. Turnbull (Autor), Edwin Yates (Autor), Elisa Vicenzi (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from death following ZIKV infection. Although heparin...