Effect of repeated oral administration of chondroitin sulfate on neuropathic pain induced by partial sciatic nerve ligation in mice

• Principais autores: Wataru Nemoto (Autor), Kotaro Yamada (Autor), Osamu Nakagawasai (Autor), Yoshiki Ogata (Autor), Masato Chiba (Autor), Ryota Yamagata (Autor), Hidetomo Sakurai (Autor), Koichi Tan-No (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2018-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

We examined whether chondroitin sulfate (CS), a compound used to treat osteoarthritis and joint pain, is effective against partial sciatic nerve ligation (PSNL)-induced neuropathic pain. Repeated oral administration of CS (300 mg/kg, b.i.d. for 20 days) resulted in inhibition of tactile allodynia ob...