Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells.

• Main Authors: Akira Kawashima (Author), Mitsuo Kiriya (Author), Junichiro En (Author), Kazunari Tanigawa (Author), Yasuhiro Nakamura (Author), Yoko Fujiwara (Author), Yuqian Luo (Author), Keiji Maruyama (Author), Shigekazu Watanabe (Author), Masamichi Goto (Author), Koichi Suzuki (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Buruli ulcer is a chronic skin disease caused by a toxic lipid mycolactone produced by Mycobacterium ulcerans, which induces local skin tissue destruction and analgesia. However, the cytotoxicity pathway induced by mycolactone remains largely unknown. Here we investigated the mycolactone-induced cel...