Genome-wide screening identified SEC61A1 as an essential factor for mycolactone-dependent apoptosis in human premonocytic THP-1 cells.

• Автори: Akira Kawashima (Автор), Mitsuo Kiriya (Автор), Junichiro En (Автор), Kazunari Tanigawa (Автор), Yasuhiro Nakamura (Автор), Yoko Fujiwara (Автор), Yuqian Luo (Автор), Keiji Maruyama (Автор), Shigekazu Watanabe (Автор), Masamichi Goto (Автор), Koichi Suzuki (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2022-08-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Buruli ulcer is a chronic skin disease caused by a toxic lipid mycolactone produced by Mycobacterium ulcerans, which induces local skin tissue destruction and analgesia. However, the cytotoxicity pathway induced by mycolactone remains largely unknown. Here we investigated the mycolactone-induced cel...