Activity of the Lactate Dehydrogenase Inhibitor Oxamic Acid against the Fermentative Bacterium <i>Streptococcus mitis/oralis</i>: Bactericidal Effects and Prevention of Daptomycin Resistance In Vitro and in an Ex Vivo Model

• Main Authors: Razieh Kebriaei (Author), Arnold S. Bayer (Author), Christian K. Lapitan (Author), Michael J. Rybak (Author), Greg A. Somerville (Author), Nagendra N. Mishra (Author)
• Format: Bog
• Udgivet: MDPI AG, 2022-10-01T00:00:00Z.
• Fag: article
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<i>Streptococcus mitis/oralis</i> is a fermentative bacterium that relies on lactate dehydrogenase to balance its redox poise and keep glycolysis active. Metabolomic analysis of an in vitro-derived daptomycin-resistant (DAP-R) <i>S. mitis/oralis</i> strain (351-D10) revealed...