Activity of the Lactate Dehydrogenase Inhibitor Oxamic Acid against the Fermentative Bacterium <i>Streptococcus mitis/oralis</i>: Bactericidal Effects and Prevention of Daptomycin Resistance In Vitro and in an Ex Vivo Model

• Главные авторы: Razieh Kebriaei (Автор), Arnold S. Bayer (Автор), Christian K. Lapitan (Автор), Michael J. Rybak (Автор), Greg A. Somerville (Автор), Nagendra N. Mishra (Автор)
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• Опубликовано: MDPI AG, 2022-10-01T00:00:00Z.
• Предметы: article
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<i>Streptococcus mitis/oralis</i> is a fermentative bacterium that relies on lactate dehydrogenase to balance its redox poise and keep glycolysis active. Metabolomic analysis of an in vitro-derived daptomycin-resistant (DAP-R) <i>S. mitis/oralis</i> strain (351-D10) revealed...