The function of peroxisome proliferator-activated receptors PPAR-γ and PPAR-δ in Mycobacterium leprae-induced foam cell formation in host macrophages.

• 主要な著者: Yuqian Luo (著者), Kazunari Tanigawa (著者), Akira Kawashima (著者), Yuko Ishido (著者), Norihisa Ishii (著者), Koichi Suzuki (著者)
• フォーマット: 図書
• 出版事項: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). In lepromatous leprosy (LL), skin macrophages, harboring extensive bacterial multiplication, gain a distinctive foamy appearance due to increased intracellular lipid load. To determine the mechanism by which M. lepra...