The function of peroxisome proliferator-activated receptors PPAR-γ and PPAR-δ in Mycobacterium leprae-induced foam cell formation in host macrophages.

• Main Authors: Yuqian Luo (Author), Kazunari Tanigawa (Author), Akira Kawashima (Author), Yuko Ishido (Author), Norihisa Ishii (Author), Koichi Suzuki (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). In lepromatous leprosy (LL), skin macrophages, harboring extensive bacterial multiplication, gain a distinctive foamy appearance due to increased intracellular lipid load. To determine the mechanism by which M. lepra...