Systematic Exploration of Privileged Warheads for Covalent Kinase Drug Discovery

• Huvudskapare: Zheng Zhao (Författare, medförfattare), Philip E. Bourne (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: MDPI AG, 2022-10-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

Kinase-targeted drug discovery for cancer therapy has advanced significantly in the last three decades. Currently, diverse kinase inhibitors or degraders have been reported, such as allosteric inhibitors, covalent inhibitors, macrocyclic inhibitors, and PROTAC degraders. Out of these, covalent kinas...