Development of a UPLCâMS/MS method for determination of pimavanserin tartrate in rat plasma: Application to a pharmacokinetic study

• Main Authors: Shixiao Wang (Author), Yang Wang (Author), Shuang Gao (Author), Yuanyuan Zhang (Author), Hanpei Wang (Author), Longshan Zhao (Author), Kaishun Bi (Author), Shaojie Wang (Author), Xiaohui Chen (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A simple, rapid and sensitive method based on an ultra-performance liquid chromatographyâtandem mass spectrometry (UPLCâMS/MS) has been developed and validated for the determination of pimavanserin in rat plasma. The analyte was extracted by protein precipitation with methanol and separated on an AC...