Development of a UPLCâMS/MS method for determination of pimavanserin tartrate in rat plasma: Application to a pharmacokinetic study

• Autores principales: Shixiao Wang (Autor), Yang Wang (Autor), Shuang Gao (Autor), Yuanyuan Zhang (Autor), Hanpei Wang (Autor), Longshan Zhao (Autor), Kaishun Bi (Autor), Shaojie Wang (Autor), Xiaohui Chen (Autor)
• Formato: Libro
• Publicado: Elsevier, 2017-12-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

A simple, rapid and sensitive method based on an ultra-performance liquid chromatographyâtandem mass spectrometry (UPLCâMS/MS) has been developed and validated for the determination of pimavanserin in rat plasma. The analyte was extracted by protein precipitation with methanol and separated on an AC...