ASPP2 Coordinates ERS-Mediated Autophagy and Apoptosis Through mTORC1 Pathway in Hepatocyte Injury Induced by TNF-α

• Main Authors: Jia Yao (Author), Hui Yang (Author), Han Wang (Author), Honglin Shi (Author), Yan Jiao (Author), Ying Zhang (Author), Dexi Chen (Author), Hongbo Shi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Though ASPP2 plays an important role in regulating cell apoptosis and autophagy in case of liver injury, there remains a lack of clarity on the molecular mechanism of ASPP2 regulating autophagy and apoptosis.Methods: A hepatocyte injury model was constructed using HL7702 cell line and TN...