Pharmacokinetics, safety, and tolerability of gepotidacin administered as single or repeat ascending doses, in healthy adults and elderly subjects

Abstract Gepotidacin, a novel, first‐in‐class triazaacenaphthylene antibiotic, inhibits bacterial DNA replication by a distinct mechanism of action. We report the pharmacokinetics (PKs), safety, and tolerability of gepotidacin following single or multiple ascending doses. Studies 1 and 2 were random...

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Main Authors: Courtney Tiffany (Author), Etienne F. Dumont (Author), Mohammad Hossain (Author), Meenakshi Srinivasan (Author), Brandon Swift (Author)
Format: Book
Published: Wiley, 2022-09-01T00:00:00Z.
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